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Molina-Garrido MJ, Mora-Rufete A, Guillen-Ponce C

P., De Raeymaecker, D

The diabetic renal microenvironment is characterized by dysregulated iron handling, impaired antioxidant capacity, and lipid metabolic reprogramming, all of which converge to promote ferroptotic vulnerability

After oral administration for 7 days with the last dose given 1 hour before the experiment, all mice were placed in a hypoxic chamber with an O 2 concentration of 8% and observed for survival rate within 15 min ( 2.4 Rat high-altitude hypoxia model and drug administration Four groups were formed by randomly assigning twenty-four male SD rats: normoxia control group (NC, physiological saline, 1 mL/100 g), hypobaric hypoxia model group (HH, physiological saline, 1 mL/100 g), ginsenosides group (GS, 100 mg/kg), and Salidroside group (Sal, 100 mg/kg)